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Figure 4
AKT Inhibitor MK2206 reduces P-S1P1 T236 and impairs TNBC invasion in Zebrafish xenografts. (a) Western blot analysis of P-S1P1 T236, S1P1, P-AKT S473, AKT, and ACTIN in MIII and MIV cells without and with MK2206 (90 nM) treatment. (b) Quantification of fluorescence intensity of tumor burden in (c, n = 3 per group). (c) Overlay of brightfield and fluorescence images of zebrafish embryos transplanted with RFP+ MIII and MIV cells and treated with DMSO or MK2206 (0.3 μM) at 3 dpt. Scale bar = 200 µm. Data are presented as Mean ± SEM.
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