ZFIN Image: Badenetti et al., 2023, Figure 4

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Figure Caption

Figure 4

Beta glucocerebrosidase knockdown does not significantly increase Nrf2/ARE reporter expression but does induce the upregulation of Nrf2-pathway-related targets. (A) Confocal Z-stack projections of 30 hpf control and Gba1 morphant fish, showing increased reporter expression in both cephalic and caudal regions of morphants. For comparison, three different morphant and control fish are depicted. All images are lateral view with anterior to the left. Scale bar: 100 μm. (B) Bar graphs showing the quantitative EGFP reporter and Nrf2 pathway-related genes expression measured in morphant and control fish RNA extracts. Data are mean ± SD of three independent biological replicates (each replicate consists of ten larvae per condition; * p < 0.05; t-test).

Acknowledgments

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