ZFIN Image: Falat et al., 2022, Fig. 1

Image

Figure Caption

Fig. 1 The laminin-111 genes, lama1, lamb1a, lamc1, are all required for proper body axis and MHB structure. (A) Schematic representation of MHB tissue structure during development. (B) Neuroepithelial cell shape changes required for MHB folding. (C?G) Representative lateral brightfield images of embryos at 24 ss, WT (C), col4a5 mutant (D), and all three laminin-111 mutants, lama1 (E), lamb1a (F), and lamc1 (G). (C?-G?) Dorsal brightfield images of the same embryos as C-G. Anterior to the left and posterior to the right in all images. Arrowheads indicate the midbrain-hindbrain boundary constriction (MHBC). M, midbrain; H, hindbrain; MV, midbrain ventricle; HV, hindbrain ventricle. Scale bars: C-G 500 ??m, C?-E? 100 ??m.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 492, Falat, E.J., Voit, G.C., Gutzman, J.H., Laminin-111 mutant studies reveal a hierarchy within laminin-111 genes in their requirement for basal epithelial tissue folding, 172-186, Copyright (2022) with permission from Elsevier. Full text @ Dev. Biol.