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Figure 5
Zebrafish HERC7c suppresses the IFN response by targeting STING, MAVS, and IRF7. EPC cells seeded in 24-well plates were transfected with 100 ng DrIFNφ1pro-luc or DrIFNφ3pro-luc and increasing doses of HERC7c (0 ng, 50 ng, 100 ng, and 400 ng), together with 300 ng of zebrafish STING (A), MAVS or IRF7 (B), and TBK1 or IRF3 (C). After 24 h, the cells were collected for luciferase assays. Error bars represent SD obtained by measuring each sample in triplicate. (*** p < 0.001, ns: no significant).
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