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Figure 2
Toxicity and safety of apatinib and pemetrexed in the zebrafish model. (a) The number of animal situations observed after apatinib treatment. (b) Treatment with 2.5 μM apatinib for 48 h caused pericardial edema (red arrow) and heart failure in all zebrafish embryos. The complications were caused due to vascular defects in the SIV (white arrow). (c) The number of animal situations observed after pemetrexed treatment. Zebrafish Strain: Tg(fli1a:EGFP)y1. Route of Administration: Soaking in 0.1% DMSO (in fish water). Animal number: Total of 20 embryos for each condition.
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