ZFIN Image: Yang et al., 2023, Figure 3.

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Figure Caption

Figure 3.

Morroniside ameliorates glucocorticoid-induced OP in a zebrafish model. (A) Schematic illustration of the experimental design for the MOR in vivo study in a zebrafish OP model. (B) Representative fluorescence images of normal and MOR-treated zebrafish. (C) Quantification of the fluorescence intensity of the spinal cord column. RT-PCR quantification of osteogenic differentiation marker genes Col I (D), OPN (E) and Runx2 (F) in the normal (Nor), OP (Ost) and MOR treatment groups. (G) Runx2, OPN and GAPDH protein levels were detected by Western blotting in zebrafish. MOR treatments significantly increased the OP-associated decline in OPN (I) and Runx2 (J) protein levels. **p< 0.01 vs. Ctl; ^#p< 0.05, ^##p< 0.01 vs. Ost. n = 6.

Acknowledgments

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