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Fig. 6
Steady state guanine levels are dramatically reduced in impdh1a KO retinas.A, a schematic of purine nucleotide synthesis pathway. B, the ratio of metabolites directly connected to Impdh enzyme activity. C, quantification from LC/MS/MS analysis of a subset of relevant metabolites and metabolites at 11:00 AM with significant changes between WT and impdh1a KO. The experiment was repeated twice, total N = 5 or 6 animals, and the error bars are standard error. impdh, inosine monophosphate dehydrogenase. ns p > 0.05, ∗ p ≤ 0.05, ∗∗ p ≤ 0.01, ∗∗∗ p ≤ 0.001.
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Full text @ J. Biol. Chem.