FIGURE 1

Generation of chd7 zebrafish mutants. (A) Schematics of Chd7 protein and chd7 gene structure. Chd7 protein contains double CHROMO domains, an ATPase domain including a DEXDc and HELICc domain, a SLIDE/SANT domain, and double BRK domains. (B) Sequence of the chd7 ^sr5 and chd7 ^sr6 mutants. Chd7 ^sr5 contains a 55-bp deletion in the fifth exon of chd7, which generated a truncation after the first chromo domain. The deletion created a 44-amino acid frame-shift followed by a stop codon. Chd7 ^sr6 has a mutation in the twelfth exon, which encodes the DEXDc domain, and causes a deletion of two amino acids, tryptophan and threonine.