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Fig. 1
FIGURE Generation of fbn1 +/? zebrafish. The conserved domains of FBN1 protein in zebrafish are shown. The red box and the red arrow indicate the target of CRISPR/Cas9 gene editing. The CRISPR/Cas9 induced a frameshift mutation containing 3?base deletion and 16?base insertion in fbn1. The inserted nucleotides are marked in red. The red dashed line indicates the 3?base deletion. WT: wildtype; TB: transforming growth factor?beta?binding protein?like
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