ZFIN Image: Ablain et al., 2022, Fig. 1

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Figure Caption

Fig. 1 a, List of the five most significant chromosomal deletions found in TCGA dataset of 363 human cutaneous melanomas. False discovery rate q-values were calculated by GISTIC. b, Linear copy number of the NECTIN1 locus in human melanoma (363 samples represented on the y axis). Blue denotes deletions, red, amplifications. The gray bar on the scale represents the focal deletion found by GISTIC analysis. c, Images of human melanoma sections stained for NECTIN1 by immunohistochemistry. Scale bar, 20 ?m. d, Quantification of overall NECTIN1 staining intensity in 180 primary melanomas and 73 melanoma metastases (mean � standard deviation (s.d.). Two-tailed t-test. e, Overall survival curves of patients with melanoma stratified according to NECTIN1 copy number status (> ?0.25: no deletion, n = 190; < ?0.25: deletion, n = 168 (log-rank test).

Acknowledgments

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