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Figure Caption
FIGURE 2 SHP2 has a central role in signaling. Schematic representation of SHP2 signaling in (left) growth factor signaling, (middle) JAK/STAT signaling and (right) PZR signaling. SHP2 binds to phosphotyrosine residues (yellow dots) in transmembrane growth factor receptors, cytokine receptors or PZR via its SH2 domains. Subsequently, RAS/MAPK signaling, PI3K/AKT signaling, STAT3/5 signaling or signaling via SRC to ERK1/2/MAPK is activated as indicated. Created using BioRender (BioRender.com).
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Full text @ Front Cell Dev Biol