Figure 4

Figure 4

Concentration-Response Curves for Mitochondrial Membrane Potential in NHBE. Curves are in order of decreasing potency based on predicted EC₅₀ values. (A) Toxicity Mix was the most potent mixture with an EC₅₀ of 50.5 µM. (B) Weighted-Toxicity Mix was the second most potent mixture with an EC₅₀ of 572 µM. (C) Abundance Mix was the least potent mixture with EC₅₀ of 1402 µM. (D) Creosote-Fire Mix did not elicit significant bioactivity compared to control, no EC₅₀ was calculated. Concentrations significantly different from control are denoted with an asterisk (*). p < 0.05 *; p < 0.01 **; p < 0.001 ***.