IMAGE

Fig. 7

ID
ZDB-IMAGE-221210-7
Source
Figures for Walker et al., 2021
Image
Figure Caption

Fig. 7

Musk depletion partially suppresses lrp4-mutant phenotype. (A,B) lrp4+/−;musk+/− trans heterozygotes have an innervation pattern indistinguishable from WT (A), whereas lrp4;musk double mutants phenocopy musk mutants with defasciculated axonal patterning labeled with Tg(mnx1:GFP) and diffuse AChR staining labeled by α-Btx (B). (C) lrp4-mutant motor axons have swellings in their innervation pattern that are opposed to large AChR clusters. (D) Although lrp4 mutants that are heterozygous for musk (lrp4−/−;musk+/−) still have some large AChR clusters similar to lrp4 mutants (orange arrows), they also have regions of the fin with smaller AChR clusters (encircled by orange line). (E-G) Quantification of the number of AChR clusters per fin (E), the median cluster size per fin (F) and the distribution of cluster sizes (5 μm2 bins) (G). ****P<0.001, one-way ANOVA with Sidak's (E) or Dunnett's (F) multiple comparisons test. n=8 (WT), 21 (lrp4+/−;musk+/−), 4 (lrp4−/−;musk−/−), 33 (lrp4−/−) and 39 (lrp4−/−;musk+/−).

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development