Fig. 2

Fig. 2 Cdx4 and FoxD3 bind near early NC cell specification genes. A. Schematic representation showing number of genes of each zebrafish NC GRN module bound by both Cdx4 at 10 hpf and Foxd3 (dark circle) at 10 and 12 hpf out of the total number of genes in the module (light circle). B. Schematic representation of Cdx4 and Foxd3 binding near genes of the NPB module (left) and premigratory module (right). C–F. Analysis of Cdx4 and Foxd3 binding near the NPB genes msx1a (C), pax3a (D), prdm1a (E), and tfap2a (F), as well as the premigratory and migratory NC genes sox9b (G), snai1b (H), id2a (I), and sox10 (J). In all panels, the plots are laid out as follows (from top to bottom): ATAC-seq profiles from foxd3-expressing cells, with called peaks below, Cdx4-Myc ChIP-seq peaks at 10 hpf, Foxd3-biotin-ChIP-seq peaks at 10 hpf, and 12 hpf, and Ref-seq annotated genes.