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Publication: Chrystal et al., 2022 - The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision
All Figures: Figures for Chrystal et al., 2022

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Fig. 1 The two principal classes of ciliopathies are considered to be mutually exclusive: they affect the functions of motile or non-motile (primary) cilia, and they have little to no genetic overlap. The two principal classes of ciliopathies are considered to be mutually exclusive: they affect the functions of motile or non-motile (primary) cilia, and they have little to no genetic overlap.

a Functional modules in motile cilia encompass at least 57 proteins, and include subunits of the Inner Dynein Arm (IDA) and Outer Dynein Arm (ODA), which confer motility, as well as subunits within radial spokes (RS) and the Nexin-Dynein Regulatory Complex (N-DRC), which regulate motility. At least 140 proteins are implicated in a wide array non-motile ciliopathies. b This study focusses on the protein CFAP20 (red). From reconstructions of motile cilia in Chlamydomonas and Tetrahymena, CFAP20 is known to form a repeating unit with PACRG (blue); these form the core of the inner junction (IJ) that runs the length of each microtubule doublet. The IJ participates in attachment of the B tubule to the A tubule to complete each of the nine doublet microtubule axoneme. The inner junction structure shown is derived from PDB file 6VE7²¹. TZ transition zone, BB basal body, L-R left-right.

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