Fig. 3

Phenotypic analysis of zebrafish mutants carrying deletions of downstream elements. A?I Dorsal images of the head region of 3-, 4- and 6-dpf wild-type (WT) (A?C), foxc1a^?CED1?3 (D?F) and foxc1a^?CED2?3 (G?I) homozygous zebrafish embryos. Both mutant lines showed the enlargement of the anterior chamber of the eye that was first noticeable at 3-dpf and became more pronounced by 6-dpf (black arrows in D?I). J?L Lateral and dorsal views of the 3-dpf wild-type (J), foxc1a^?CED1?3 (K) and foxc1a^?CED2?3 (L) homozygous zebrafish embryos. Please note no obvious morphological changes (aside from ocular defects presented in A?I) in mutant embryos. M Comparison of the anterior chamber area in wild-type and mutant embryos at 3-, 4-, and 6-dpf. *: p < 0.05; **: p < 0.01; ***: p < 0.001; ****: p < 0.0001