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Figure 6

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Publication: Khrystoforova et al., 2022 - Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation
All Figures: Figures for Khrystoforova et al., 2022

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Figure 6

lrp5^-/- scales display a larger demineralized area and TRAP positive area. (A) von Kossa staining of lrp5^-/- scales revealed significantly more demineralized area (t-test, n of scales per group=120-130) than of control siblings scales. (B) TRAP staining of lrp5^-/- scales indicates significantly larger TRAP area compared to lrp5^+/+ (t-test, n of scales=95-101). Scale bar=100µm. (C) Branching of lepidotrichia in lrp5^+/+ fins occurs in distal segments (red arrows), meanwhile lrp5^-/- fish display bifurcation in proximal segments of lepidotrichia (C, red arrows). The number of normally branched fin rays is significantly lower in lrp5^-/- compared to lrp5^+/+ siblings. (D) Schematic representation of excessive branching in lrp5^-/-. Results in A, B and C are expressed as mean SD.

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