ZFIN Image: Iribarne et al., 2022, FIGURE 8

Image

Figure Caption

FIGURE 8

Model of inflammation regulating the regenerative response in acute and chronic retinal damage in zebrafish. Diagram representing microglia/macrophages activation and polarization upon NMDA-acute injury or gosh chronic mutant retinal damage in zebrafish to induce regeneration. This acute injury model stimulates an early pro-inflammatory response, which then switches to an anti-inflammatory profile. This chronic injury model stimulates a dominant anti-inflammatory response, accompanied by a mild pro-inflammatory response. Modulating inflammation can inhibit or amplify the regeneration capacity via regulating the presence of M1-like pro-inflammatory microglia/macrophages.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol