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FIGURE 8
Model. Based on the literature, we hypothesized HS interaction with Tmem184a is involved in modulation of Vegfr2 signal transduction. VEGF binding to Vegfr2 induces a signaling cascade responsible for the EC survival, permeability, migration, and proliferation necessary for angiogenesis. The present study provides evidence supporting this hypothesis.
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Full text @ Front. Physiol.