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Fig. 9

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Publication: Cao et al., 2022 - CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response
All Figures: Figures for Cao et al., 2022

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Fig. 9 Proposed model illustrating the different antibacterial mechanisms of zebrafish CD44a variants during <italic>E. piscicida</italic> infection.

CD44a deficiency regulates the expression levels of many genes involved in p53 signaling, apoptosis and autophagy, which leads to inhibition of apoptosis and induction of autophagy in the case of E. piscicida infection. In zebrafish, two CD44a variants including CD44a_tv1 and CD44a_tv2 are identified. The zebrafish CD44 variants exert protective effects against E. piscicida infection. Both zebrafish CD44a_tv1 and CD44a_tv2 can promote the nucleoplasmic translocation of p53 and interact with p53 in the cytoplasm. The antibacterial effect of zebrafish CD44a_tv1 is depending on the CASP8-mediated apoptosis, whereas the antibacterial effect of zebrafish CD44a_tv2 is dependent of the cytoplasmic p53-mediated inhibition of autophagy.

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