FIGURE 6

FIGURE 6

Wnt/β-catenin signalling upregulation can rescue FGR anomalies. Downregulation of Wnt/β-catenin signalling with 5 µM XAV939 (XAV) inhibitor does not rescue body length or eye size, and worsens the pericardial effusion under hypoxia. Upregulation of Wnt/β-catenin signalling with 40 µM SB216763 (SB) agonist can rescue the body length and the pericardial effusion under hypoxia. All embryos, at 3 dpf, are displayed in lateral view, anterior to the left. For display purposes, images of control embryos under normoxia and hypoxia correspond to control images of Figure 5, as the same control conditions were used for both Stat3 and Wnt experiments. Sample size: n = 15; * = p < 0.05; ** = p < 0.01; *** = p < 0.001; **** = p < 0.0001; ns = not significant; R.R. = Relative Ratio. Test: One-way ANOVA followed by Tukey’s test.