IMAGE

Figure 5

ID

ZDB-IMAGE-220827-27

Genes

DsRed
EGFP

Publication

Elfatih et al., 2022 - Analysis of incidental findings in Qatar genome participants reveals novel functional variants in LMNA and DSP

All Figures

Figures for Elfatih et al., 2022

Image

Figure Caption

Figure 5

Zebrafish LMNA model heart structure abnormalities. Modeling Qatar Genome Programme human LMNA cardiac variant produced abnormal heart chambers in LMNA zebrafish model. (A) Proportion of heart abnormalities, including valve defects and abnormal heart chamber shape in the four experimental groups. (B) LMNA zebrafish heart 3D structure at 72 hours post fertilization (hpf). Transgenic embryos (Tg:gata1: dsRed, cmlc2:eGFP), expressing red fluorescent red blood cells and green hearts) showing the abnormal cardiac chambers structure (Atrium: A, Ventricle: V). AV valve: Control (n = 3), lmna MO (n = 5), MO + LMNA^Variant (n = 14), and MO + LMNA^WT (n = 0). Ventricular shape: Control (n = 2), lmna MO (n = 14), MO + LMNA^Variant (n = 28), and MO + LMNA^WT (n = 5). Atrium shape: Control (n = 0), MO (n = 10), MO + LMNA^Variant (n = 16), and MO + LMNA^WT (n = 1).

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.