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Fig. 1

ID: ZDB-IMAGE-220822-16
Publication: Agarwala et al., 2022 - Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy
All Figures: Figures for Agarwala et al., 2022

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Fig. 1

Single hematopoietic stem and progenitor cells (HSPCs) lodge in a perivascular region of the larval kidney niche.

(A) Snapshot of single optical sections (XY, XZ, YZ planes) from light sheet live image of a Runx:GFP;flk:mCherry double transgenic zebrafish larva. A single Runx:GFP⁺ HSPC (white arrowhead) is lodged in a perivascular region lateral to the dorsal aorta (DA). (B) Detail of optical sections (1 µm steps) through the single lodged Runx:GFP⁺ HSPC in (A). mCherry⁺ endothelial cells contact the HSPC and form a surrounding pocket. The +5 µm section is also shown in XZ and YZ planes. Abbreviations: DA, dorsal aorta; SeA, intersegmental artery; SeV, intersegmental vein; PCV, posterior cardinal vein; CCV, common cardinal vein; ISVs, intersegmental vessels; D, dorsal; V, ventral; A, anterior; P, posterior.

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