ZFIN Image: Sertori et al., 2022, Figure 6

Image

Figure Caption

Figure 6

Phenotypic analysis of the L1CAM^Q497H knockin mice. (A) Flow cytometric analysis of the frequencies of thymocytes from wildtype (WT) and hemizygous L1cam^497H mutant mice. (B) The total and subpopulations of thymic cellularity are shown in bar graphs. The following populations are graphed: DN, CD4^-CD8^-; DP, CD4⁺CD8⁺; CD4⁺; CD8⁺; DN1, CD4^-CD8^-CD25^-CD44⁺; DN2, CD4^-CD8^-CD25⁺CD44⁺; DN3, CD4^-CD8^-CD44^-CD25⁺; DN4, CD4^-CD8^-CD44^-CD25^-. (C) Flow cytometry analysis of splenic CD4⁺ and CD8⁺ T cells, B (B220⁺IgM⁺) and NK (CD3^-CD122⁺NK1.1⁺) cells in WT and L1cam^Q497H mutant mice. (D) The total and subpopulations of splenic cellularity are shown in bar graphs. (E) Flow cytometry analysis of CD44 and CD62L staining of CD4⁺ and CD8⁺ T cells. (F) The frequency of CD44⁺CD62L⁺ in CD4⁺ and CD8⁺ T cells is shown in bar graphs. Data are representative of 2 independent experiments performed. No statistically significant differences were found in any of the indicated populations.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Immunol