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Publication: Hattab et al., 2022 - Pseudomonas Synergizes with Fluconazole against Candida during Treatment of Polymicrobial Infection
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Fig. 1

FIG 1 Fluconazole is synergistic with P. aeruginosa against C. albicans and C. glabrata in vitro. (A) C. albicans + P. aeruginosa + FLC shows a fungicidal effect after coculture. P. aeruginosa and C. albicans were inoculated at 2 × 10⁵/mL and FLC was added at 12.5 μg/mL. Drops (3 μL) of serial 10x dilutions of cocultures were plated on YPD containing antibiotics. Representative of >20 independent experiments. (B) Fungicidal effect of P. aeruginosa with FLC for multiple FLC-resistant and -sensitive clinical isolates of C. albicans and C. glabrata when tested at >2x MIC₅₀. MIC₅₀ was tested separately and supra-MICs of FLC were used (per measurements relevant for our assays; Table S1). Representative results of at least three independent experiments are shown.

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