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FIGURE 5 Non-conservation of GBSs in Gli1 and Ptch1 loci in vertebrates. (a, b) Gli1/3 ChIP-seq and ATAC-seq peak call results are displayed in the UCSC genome browser with the Multiz Alignments track. The Gli1 (a) and Ptch1 (b) loci in the mouse genome (mm10) are shown. In the Gli1 locus, the Multiz Alignment tracks of mammals and non-mammals are highlighted by different colors. In the Ptch1 locus, the Multiz Alignment tracks of tetrapods and teleosts are highlighted by different colors. The positions of GBSs are highlighted in yellow, and are indicated by sequential numbers in the Gli1 and Ptch1 loci independently. (c) The Gli binding motif represented by the sequence logo. (d) The DNA sequence of each GBS indicated in (a) and (b). The extent of conservation of each GBS is shown in the “Conserved in” column. More detailed conservation profiles are presented in Figure S7