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Fig. 2.

ID: ZDB-IMAGE-220717-101
Publication: Ross et al., 2021 - Ankfn1-mutant vestibular defects require loss of both ancestral and derived paralogs for penetrance in zebrafish
All Figures: Figures for Ross et al., 2021

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Figure Caption

Fig. 2.

Targeted mutagenesis of Ankfn1 homologs. Peptide and genomic sequences for targeted sites in D. rerio Ankfn1 homologs. a) Ankfn1 on chromosome 12 is a derived paralog that includes two ANK and one FN3 domain but no RA domain. b) Ankfn1-like on chromosome 24 is an ancestral paralog including the RA domain. The targeted GLYLGYLK site is highlighted in yellow. CRISPR guide RNA sites are underlined and protospacer adjacent motifs are boxed in each reference sequence. Recovered mutations are shown with deleted base pairs as dashes and insertion of a frame-shifting duplicated sequence (gray shadow) at chromosome 24 shown in a box below the caret.

Acknowledgments

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