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Fig. 3
Ocular phenotype in cep290 mutants. (A) Wholemount TUNEL staining (green) comparing Wt eyes, untreated cep290 eyes (Mt), and eyes from Mt embryos treated with either 3 μM Ataluren (AT) or 3 μM AT plus 1 μM Amlexanox (AM). Sections were counterstained with DAPI. Size bar = 20 μm. (B) Visual background adaptation assay. In Wt embryos the melanophores (arrows) contract after 15 minutes of bright light, but not in cep290 embryos (Mt). Treatment with AT or AT/AM resulted in contracted melanophores in Mt embryos.
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