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Fig. 1
Toxicity testing for Amlexanox in wildtype (wt) zebrafish embryos. (A) Survival curves for increasing concentrations of Amlexanox (solid line) and Ataluren (dotted line) after 6 days continuous exposure. (B) At 6 dpf, Amlexanox (1 μM) and Ataluren (3 μM) had no adverse effects on ocular histology or body shape. Size bar = 50 μm. (C) At 48 hpf, 5 μM Amlexanox resulted in a curved tail, whereas at 10 μM a short, bent tail, pericardial edema (arrow) and abnormal brain and eye development was present. Exposure to 30 μM Ataluren resulted in curved tail and pericardial edema (arrow).
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