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Fig. 4
Zebrafish innate immune cells regulate PANC1, BxPC3, and AsPC1 tumor progression. (A) Representative confocal images of PANC1, BxPC3, and AsPC1 xenografts in embryos co-injected with PBS, L-PBS or liposome-clodronate (L-clodronate) at 1 dpi and 4 dpi. (B) Relative tumor cell growth for PANC1, BxPC3, and AsPC1 in PBS, L-PBS, or L-clodronate-treated groups. Results are from nine different individuals (* p < 0.05, t test). (C) Representative confocal images of PANC1, BxPC3, and AsPC1 xenografts in WT and irf8?/? mutant embryos at 1 dpi and 4 dpi. (D) Relative tumor growth of PANC1, BxPC3, and AsPC1 in WT and irf8?/? mutant embryos. Results are shown as means ± SEM from nine different individuals (* p < 0.05, t test). dpi, days post injection. Scale bar, 50 µm.