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Publication: Zhang et al., 2022 - Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery
All Figures: Figures for Zhang et al., 2022

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FIGURE 2

Morphological, survival and behavioral analysis of sv2a knockout zebrafish. (A) Representative images of sv2a^+/+, sv2a^+/–, and sv2a ^–/– zebrafish larvae at 6 dpf. Scale bar 1 mm. (B) Comparison of mean body length of sv2a^+/+ (n = 8), sv2a^+/– (n = 8), and sv2a ^–/– (n = 8) zebrafish larvae at 6 dpf (mean ± SD). (C) Kaplan-Meier curve demonstrating survival of sv2a^+/+ (n = 94), sv2a^+/– (n = 208), and sv2a^–/– (n = 92) zebrafish larvae. Significant larval death in sv2a^–/– larvae can be observed in a time-dependent manner. Statistical analysis was performed using Log-rank (Mantel-Cox) test (****p < 0.0001). (D) Locomotor activity of sv2a^+/+ (n = 15), sv2a^+/– (n = 53), and sv2a^–/– (n = 40) zebrafish larvae at 6 dpf. Data were assessed over the total tracking period of 10 min, normalized to sv2a^–/– larvae, and expressed as normalized total velocity (%) (mean ± SD). Statistical analysis was performed by one-way ANOVA followed by Dunnett’s multiple comparison (***p < 0.001, ****p < 0.0001). Data were collected from four independent experiments.

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