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Fig. 3
Whole-brain oedema, ventricular dilatation, and cerebral hernia in cldn5a-/- with brain edema (BE). Histology of and HE staining on zebrafish brain sections at 22 dpf. In the forebrain and midbrain, cldn5a-/- with BE had a round outline and exhibited serious brain parenchymal edema and exaggerated ventricular dilatation. A yellow dot line labels the brain hernia in cldn5a-/- with BE. Black dot lines describe the brain ventricles. n > 3 brains analyzed per group. Scale bars: 100 μm
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