ZFIN Image: Li et al., 2022, Fig. 2

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Figure Caption

Fig. 2

Fetal brain edema (BE) in cldn5a^-/- zebrafish. A, B Around 70% of cldn5a^-/- mutated zebrafish larvae show an obvious morphology with a tiny body and serious swollen head (BE), and the rest of the homozygous mutants have normal morphology (NM) but a tiny body. cldn5b^-/- shows normal and healthy morphology as wild types. Enlarged figures of the head regions are shown in the lower panel. Red dotted lines figure out the profile of the skull. C cldn5a^-/- larvae showed a tiny body at both 16 and 30 dpf. D-F Dissected brain tissues of 16 dpf-old larvae from wild types, cldn5a^-/- with BE, and cldn5a^-/- with NM brains. The ratio of vertical/horizontal length of the whole-brain was analyzed. The ratios of the brain area to head area was calculated and compared. V, vertical. H, horizontal. n > 3 brains analyzed per group. Scale bars: 1 mm. Data are presented as mean ± SEM. *P < 0.05, ***P < 0.005, ns means no significance

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