Fig. 8

Fig. 8 Fig 8. Comparison of arriving probabilities by simulations. (A) Probability distributions of first passage times for simulated cells at a distance of 200 ?m. Model parameters calculated for the respective experimental conditions were used for simulations as given in Figs 5 and 6. There is a surge of WT neutrophils reaching their target after 20 min, whereas all other cell types show a delayed arrival. (B) Percentage of cells arriving at the target that is located at a distance a from the starting points of the cell ensemble. All simulated wildtype cells arrive at the target within 5 h, whereas CXCR2 inhibition and/or TRPC6 ablation markedly reduce the number of cells arriving at their target.