ZFIN Image: Sun et al., 2022, Figure 5

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Figure 5

Inhibition of the Notch signaling pathway after liver cancer induction reduced cancer cell migration and improved survival. (A) Tg(fabp10a:Tet3G;TRE3G:kras^G12V -ZsGreen1) with Tg(Hsp70l:dnMAML-GFP) double transgenic fish line treatment strategy to observe the migration of cancer cells. (B) Zebrafish larvae were classified into three classes, I, II, and III, by the number of cancer cells outside the liver and the number of locations of metastases. (C) The proportion of the total number of larvae in different metastasis classes in the kras^G12V+ (n = 46) and kras^G12V+ and dnMAML+ (n = 130) groups at 9 dpf. (D) Kaplan–Meier survival curves of the DOX-induced kras^G12V+ (n = 191) and kras^G12V+ and dnMAML+ (n = 163) groups. p values for survival curves were calculated by log-rank test. Scale bars, 100 μm.

Acknowledgments

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