ZFIN Image: Wang et al., 2022, Figure 5

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Figure Caption

Figure 5

Effects of FRA on the expression levels of bile acid transporters and components of the JNK/p53 pathway. FRA inhibited mRNA expression of the bile acid transporters P-gp (A), Bsep (B), and NTCP (C), and increased those of the apoptotic genes JNK1 (D), caspase-3 (E), and p53 (F). The protein levels of JNK, p-JNK (H), p53, p-p53 (I), Bax (J), and cleaved caspase-3 (K) were determined by western blot analysis. GAPDH was used as an internal reference to normalize the results (G). Data are presented as the mean ± SD. Each experiment was performed 3 times with 40 randomly selected zebrafish larvae. * p < 0.05 vs. control; ** p < 0.01 vs. control; *** p < 0.001 vs. control.

Acknowledgments

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