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Fig. 2
Figure 2. Altered gene expression in zebrafish larvae following exposure to MK801, DMP and morphine, and morphine withdrawal. (A) Effect of short-term (3-day) drug exposure on expression of akt1 (F (3,32) = 1.386, p = 0.265), pi3k (F (3,32) = 1.127, p = 0.299), slc64a (F (3,32) = 1.721, p = 0.182), creb1 (F (3,32) = 0.522, p = 0.667) and adamst2 (F (3,32) = 2.771, p = 0.058). (B) Effect of long-term (10-day) drug exposure on expression of akt1 (F (3,32) = 14.546, p < 0.001), pi3k (F (3,32) = 6.650, p < 0.001), slc64a (F (3,32) = 25.115, p < 0.001), creb1 (F (3,32) = 29.607, p < 0.001) and adamst2 (F (3,32) = 90.337, p < 0.001). (C) Effect of short-term morphine exposure followed by 5-day withdrawal on expression of akt1 (t (16) = 8.945, p = 0.003), pi3k (t (16) = 8.082, p = 0.001), slc6a4 (t (16) = 5.591, p = 0.001), creb1 (t (16) = 6.394, p = 0.001), adamts2 (t (16) = 0.306, p = 0.064). (D) Effect of long-term morphine exposure followed by 5-day withdrawal on expression of akt1 (t (16) = 8.945, p = 0.003), pi3k (t (16) = 27.493, p < 0.001), slc6a4 (t (16) = 2.445, p = 0.058), creb1 (t (16) = 6.102, p < 0.001), adamts2 (t (16) = 5.709, p = 0.001). Data expressed as mean ± SEM, n = 50 of 3 independent experiments. Different lowercase letters indicate statistically significant values, p < 0.05. DMP: domperidone.
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Full text @ Int. J. Mol. Sci.