ZFIN Image: Dai et al., 2022, Fig. 6

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Figure Caption

Fig. 6 Schematic presentation of gene-expression alterations and gene lesions identified in T-ALL. (Left) Genomic aberrations in pediatric T-ALL, and (Right) illustration of those in adult T-ALL. Gene fusions and mutations (>1%) and their subcellular localizations from cell surface membrane through cytosolic compartments to cell nucleus are represented. Mutations are illustrated in the ellipse and in different colors. Fusions and mutations that are significantly enriched in pediatric T-ALL are marked with blue stars, while those significantly enriched in adult T-ALL are marked with red stars. Genes whose overexpression is most likely due to fusions are marked with red arrows. LCK and BCL2 overexpression may represent drug targets and are labeled with arrowheads.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA