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Figure 2
Figure 2. (A) Phylogenetic analysis of GFRα1 predicted amino acid sequences across vertebrates. Zebrafish Gfrα1a and 1b (both underlined) are clustered with other fish-specific Gfrα1a (yellow box) and Gfrα1b (green box) sequences, respectively, forming two separate subclades. Note that the GFRA1 sequences from other vertebrates (mammals, birds, reptiles, amphibians and Chondrichthyes) formed a separate clade (brown box). Branch values represent posterior probabilities obtained by Bayesian analysis (see Table S1). (B,C) Genomic organization and synteny comparisons among human GFRA1, rodents Gfrα1 and zebrafish gfrα1b (B) or zebrafish gfrα1a (C). The syntenic regions were analyzed according to the alignment of the target genes and genomic annotation available in the GenBank database (National Center for Biotechnology Information and Ensembl).
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