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Figure 2
Figure 2. Ultrastructural analysis of skeletal muscles of 120 hpf zebrafish larvae exposed to lovastatin (LOV) and L-carnitine (LOV+LC200) treatment. TEM micrographs show (A,A?,A??) NT (non-treated larvae); (B,B?,B??) LOV (0.5 ?M lovastatin); (C,C?,C??) larvae incubated in a mixture of LOV+LC200 (0.5 ?M lovastatin and 200 ?M L-carnitine). Light blue arrows indicate sarcomeric filaments within subsarcolemmal regions; yellow arrowheads indicate delamination of filaments within sarcomeres; note the disruption of sarcomeric filaments in skeletal muscles of lovastatin-treated larvae (red asterisks); scale bar = 1 µm.
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