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Figure 10
Figure 10. Summary of the effects of Gdnf in the zebrafish spermatogonial niche. Gdnf is a germ cell growth factor which acts on type A spermatogonia and their surrounding Sertoli cells in autocrine- and paracrine-dependent manners, respectively. The Gdnf receptor, named Gfrα1a, is expressed in type A spermatogonia (early spermatogonia, with higher expression in types Aund and Adiff) and Sertoli cells. The main actions of Gdnf are: (1) the creation of new available niches; (2) support of the development of early differentiating spermatogonial cysts; and (3) blocking of late spermatogonial differentiation.
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