ZFIN Image: Li et al., 2022, Figure 5

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Figure 5

PFN2 promotes proliferation and migration of ECs, as well as tube formation and reaches the maximum level in 10-day embryo. (A) The mRNA levels of PFN2 and VEGFA at different developmental stages of gerbils (n = 15) embryo (prenatal), brain and heart (postnatal). (B) PFN2 significantly promoted proliferation of HUVECs (n = 3) and RBMECs (n = 3), as well as showed a positive effect on migration of HUVECs (n = 3) and RBMECs (n = 3). (C) The tube length in PFN2-overexpressing ECs (OE) was significantly increased than that in blank CTL and PFN2 knockdown ECs (KD), n = 3. *p < 0.05, one-way ANOVA and repeated-measures ANOVA (Tukey).

Acknowledgments

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