ZFIN Image: Li et al., 2022, Figure 4

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Figure 4

Exosomal PFN2 enhances the proliferation ability of ECs and OE-exo treated zebrafish showed significantly increased vessel number than exo and control. (A) The exosomes secreted from ECs were identified by electron microscopy. (B) PFN2 expression in exosomes (n = 3, the expression levels were normalized to control). (C) Exosomes could be internalized by ECs. (D) PFN2 and PCNA expression levels in CTL, exosomes from normal ECs (exo), PFN2-overexpressing ECs (OE-exo), and PFN2 knockdown ECs (KD-exo), n = 3, and the expression levels were normalized to control. (E) OE-exo-treated zebrafish showed significantly increased vessel number than exo and control. Exo, exosomes from normal ECs; OE-exo, exosomes from PFN2-overexpressing ECs; CTL, PBS as control. *p < 0.05, one-way ANOVA (Tukey).

Acknowledgments

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