FIGURE 3

FIGURE 3

Association of miR-29b-3p expression with its methylation status in eight patients with CHD. (A and B) Methylation status of the promoter region of the miR-29b-1 gene and miR-29b-2 gene. The black and white circles represent methylated and unmethylated CpG dinucleotides, respectively. (C) Correlations between miR-29b-3p expression and the methylation status of the miR-29b-1 gene (r = −0.7074, p = 0.0497, and N = 8). (D) Correlations between miR-29b-3p expression and the methylation status of the miR-29b-2 gene (r = −0.4895, p = 0.2182, and N = 8). (E) Correlations between miR-29b-3p expression and the methylation status of CpG 7 located in the miR-29b-2 gene (r = −0.7236, p = 0.0425, and N = 8). (F) Correlations between miR-29b-3p expression and the methylation status of CpG 8 located in the miR-29b-2 gene (r = −0.7124, p = 0.0474, and N = 8). Spearman’s correlation tests were used.