IMAGE

Fig 7

ID

ZDB-IMAGE-220426-35

Genes

mCherry
YFP

Publication

Gibson et al., 2022 - Blood vessel occlusion by Cryptococcus neoformans is a mechanism for haemorrhagic dissemination of infection

All Figures

Figures for Gibson et al., 2022

Image

Figure Caption

Fig 7 Cryptococcal infection leads to increased tension across VE-cadherin.

A-C Infection of FRET tension reporter (VE-cadherin-TS) transgenic zebrafish line with 1000 cfu mCherry C. neoformans A-B FRET = YFP signal via FRET with excitation of CFP, CFP = CFP signal with direct excitation of CFP, YFP = YFP signal with direct excitation of YFP. A images of non-infected control vessels B Image showing infected fish, vessel containing a mass (left) and a vessel without a mass (right) C FRET analysis of infected fish with or without masses and non-infected controls larvae (n = 2, 4–7 larvae per repeat, +/- SD, **p<0.01, Kruskal-Wallis test, where vessel fluorescence was measured at each side of vessel) D Proportion of infected fish with disseminated infection. 7 repeats, 10 zebrafish larvae per repeat per group. P = 0.036 unpaired t-test.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Pathog.