ZFIN Image: Pan et al., 2022, FIGURE 4

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FIGURE 4

The sex reversal of sycp3 mutant fish is caused by germ cell apoptosis and can be compensated by additional tp53 mutation. (A). The immunostaining of apoptotic marker Caspase-3 (Wilson, High et al.). DAPI staining is blue for nuclei. (B). Quantification results of Caspase-3. Apoptotic germ cells are increased in the 1 month old sycp3^as8d/as8d gonad. (C). The sex ratios of tp53^-/-;sycp3^as8d/as8d mutants. While sycp3^as8d/as8d fish are all males, many females have the tp53^-/-;sycp3^as8d/as8d genotype. Blue bar represents males and the red bar represents females.

Acknowledgments

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