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Figure 2
Figure 2. A set of microphotographs and a graph documenting inhibition of 5 mM CoCl2-derived abnormal angiogenesis of intersegmental vessels (ISVs) resulting from co-treatment with dopaminergic agonists in 3 dpf Tg(Fli-1:EGFP) zebrafish larvae. (a) The control untreated larva presented normal morphology and distribution of ISVs; (b) 5 mM CoCl2 exposure promoted increased protrusive/regressive activity (arrowhead), branching (arrow) and swelling (asterisk). (c–f) Co-treatment with 2.5 µM/L bromocriptine, 2.5 µM/L cabergoline, 2.5 µM/L pergolide and 2.5 µM/L bevacizumab, respectively, resulted in significant inhibition of improper ISVs development. (g) The graph presenting the number of all abnormalities found in investigated groups (one-way ANOVA, GraphPad Prism 5, *** p < 0.001; ** p < 0.01). PCV—posterior cardinal vein; DA—dorsal aorta; ISV—intersegmental vessel; DLAV—dorsal longitudinal anastomotic vessel.
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