Kif15 inhibition results in decreased hair cells (HCs) in the inner ear. (A–C) The gross morphology of otic vesicle in different groups at 48 hpf using the white light field microscope. u, utricle; s, saccule. Scale bar is 20 μm. (D–F) Representative images of utricular HCs in different groups at 48 hpf. (G–I) Representative images of saccular HCs in different groups at 48 hpf. White star labels the HC. (J) Quantification of the number of HCs in utricle and saccule in control-MO (Con-MO) group (n = 22), Kif15-deficient morphants (n = 22), and Kif15-MO + Kif15 mRNA group. Data are recorded as mean ± SEM. **p < 0.01, ***p < 0.001 vs. Con-MO group; ##p < 0.01 vs. Kif15-MO group; NS, no significance.
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Full text @ Front. Mol. Neurosci.
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