ZFIN Image: Ahmed et al., 2022, Figure 8.

Image

Figure Caption

Figure 8. Summary of developmental and molecular events that underlie Strip1 function in inner retinal circuit formation.

(A) In wild-type retina, Strip1 suppresses Jun-mediated proapoptotic signals, probably through the STRIPAK complex, to maintain retinal ganglion cells (RGCs) during development. In the absence of Strip1, Jun is activated in RGCs leading to severe degeneration of RGCs as early as 2 dpf. Subsequently, cells in the inner nuclear layer (INL) abnormally infiltrate the ganglion cell layer (GCL) leading to a disrupted inner plexiform layer (IPL). (B) Proposed model for Strip1’s role within RGCs to regulate amacrine cell (AC) positioning and IPL formation. In wild type, Strip1 regulates (1) RGC survival to prevent AC infiltration, and (2) RGC dendritic patterning to promote RGC–AC interactions. In strip1^rw147 mutants, both mechanisms are perturbed, leading to AC infiltration, increased AC–AC interactions, and IPL defects. In Bcl2-rescued strip1^rw147 mutants, survived RGCs prevent AC infiltration. However, RGC dendritic defects lead to increased AC–AC interactions and ectopic IPL formation.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Elife