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Fig 11

ID: ZDB-IMAGE-220319-60
Publication: Liu et al., 2022 - Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration
All Figures: Figures for Liu et al., 2022

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Figure Caption

Fig 11 Working model for the development of rod photoreceptors in the zebrafish.

There may be two types of rod precursors defined as nrl-dependent and nrl-independent in the zebrafish retinas. The former is responsible for the production of rods at embryonic stage, and knocking out nrl abolishes the differentiation into rods (left panel). The latter is responsible for the production of rods at the juvenile and adult stages. In the presence of nrl and mafba, these cells differentiate into rods. Knocking out nrl does not severely affect the production of rods from these cells but causes abnormal expression of rod- and cone-specific genes and a progressive increase of green cones (M-cones) with age. Knocking out both nrl and mafba eliminates all rods, suggesting that mafba also plays an important role in the fate determination of this type of rods (right panel).

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